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Biolog - Technology Access Initiative
A rapid and comprehensive phenotype analysis of bacteria, fungi and mammalian cells.
The Biolog phenotyping technology (540kb pdf) is a novel platform for high-throughput simultaneous screening of bacteria, fungi and mammalian cells for ~2,000 phenotypes.
The phenotypes are monitored in ‘real time’ to follow the kinetics of respiration/metabolism from a few hours to over a week of incubation.
VLA, in agreement with Biolog and their UK distributor Technopath, is now offering access to this exciting new technology to provide
- extensive cellular profiles,
- identification of gene functions,
- validation of drug targets,
- lead validation,
- streamlining of optimisation and toxicology studies
- and many other functions.
This technology has been used widely and now has an established track record with many publications in the scientific press. A conference was also held in Florence in 2008.
Substrates on the Biolog panels.
A series of 96 well plates, each containing a unique testable analyte, has been designed for use with prokaryotic and eukaryotic cells.
For the prokarotic cells (199kb pdf) a total of 20 plates have been designed and cover carbon sources, nitrogen sources, phosphorus sources, sulphur sources, biosynthetic pathway substrates, peptide nitrogen sources and sensitivities to ion concentration, pH and antimicrobials.
Similarly for the eukaryotic cells (1,109kb pdf) a total of 14 plates have been designed and cover carbon sources, nitrogen sources and sensitivities to ion concentration, hormones, cytokines, growth factors, metabolic effectors and anti-cancer agents.
Seminar day
The Biolog technology access initiative was launched at a seminar day on 12 November 2008 at VLA Weybridge.
Phengenix & Identibac
Not only do we offer the Biolog access initiative but we also offer a range of gene array and sequencing technologies that compliment phenotyping. If you are interested, please view the Phengenix services page and Identibac website.
If you would like further information on how you may access this technology and to discuss service delivery, please contact:
Prof Martin Woodward
E-mail: m.j.woodward@vla.defra.gsi.gov.uk
Tel: 01932 357582