Papers
Statutory and Exotic Bacterial Diseases
Al-Momani W, Nicholas RAJ 2006
Small ruminant mycoplasmoses with
particular reference to the Middle East.
Perspectives in Agriculture, Veterinary
Science. Nutrition and Natural Resources
1 (4) 1-11.
Ayling RD, Bisgaard-Frantzen S,
March JB, Godinho K, Nicholas RAJ
2005
Assessing the in vitro effectiveness of
antimicrobials against Mycoplasma
mycoides subsp. mycoides small-colony
type to reduce contagious bovine
pleuropneumonia infection.
Antimicrobial Agents and Chemotherapy
49 (12) 5162-5165.
Ayling RD, McAuliffe L, Bisgaard-
Frantzen S, Bashiruddin S, Miles K,
Nicholas RAJ 2005
Mycoplasma ovipneumoniae: recent
developments in diagnosis and the in
vitro susceptibility to antimicrobials.
In: Proceedings 6th International Sheep
Veterinary Congress, 17-21 June 2005,
134-135.
Ayling RD, Nicholas RAJ 2005
Treatment of mycoplasma infections:
susceptibility of field isolates and
outcome of treatment; recovered cattle:
risk or bonus?
In: 38th Annual Conference of the
American Association of Bovine
Practitioners held at Salt Lake City, on the
22nd - 24th September 2005.
Bigi F, Garcia-Pelayo MC, Nunez-
Garcia J, Peralta A, Caimi KC, Golby P,
Hinds J, Cataldi A, Gordon SV,
Romano MI 2005
Identification of genetic markers for
Mycobacterium pinnipedii through
genome analysis.
FEMS Microbiology Letters 248 (2) 147-
152.
Buddle BM, Aldwell FE, Skinner MA, Lisle
GW de, Denis M, Vordermeier HM,
Hewinson RG, Wedlock DN 2005
Effect of oral vaccination of cattle with
lipid-formulated BCG on immune
responses and protection against bovine
tuberculosis.
Vaccine 23 (27) 3581-3589.
Cadmus S, Palmer S, Okker M, Dale J,
Gover K, Smith N, Jahans K,
Hewinson RG, Gordon SV 2006
Molecular analysis of human and bovine
tubercle bacilli from a local setting in
Nigeria.
Journal of Clinical Microbiology 44 (1)
29-34.
Chambers MA, Gavier-Widen D,
Hewinson RG 2006
Histopathogenesis of experimental
Mycobacterium bovis infection in mice.
Research in Veterinary Science 80 (1) 62-
70.
Christian M 2005
Johne’s disease vaccine.
Veterinary Record 157 (11) 327.
Commander NJ, Thirlwall RE,
Stack JA, Macmillan AP 2005
A novel vaccine for protection of sheep
and goats against Brucella melitensis,
which does not compromise current
diagnostic tests.
In: Proceedings 6th International Sheep
Veterinary Congress, 17-21 June 2005,
164-165.
Dawson CE 2005
Anti-brucella antibodies in pinnipeds of
Australia.
Microbiology Australia (26) 87-89.
Dean GS, Rhodes SG, Coad M,
Whelan AO, Cockle PJ, Clifford DJ,
Hewinson RG, Vordermeier HM 2005
Minimum infective dose of
Mycobacterium bovis in cattle.
Infection and Immunity 73 (10) 6467-
6471.
Diggle P, Zheng P, Durr P 2005
Nonparametric estimation of spatial
segregation in a multivariate point
process: bovine tuberculosis in Cornwall,
UK.
Journal of the Royal Statistical Society
Series C - Applied Statistics 54 (3) 645-
658.
Donnelly CA, Woodroffe R, Cox DR,
Bourne FJ, Cheeseman CL,
Clifton-Hadley RS, Wei G, Gettinby G,
Gilks P, Jenkins H, Johnston WT,
Le Fevre AM, McInerney JP, Morrison WI
2006
Positive and negative effects of
widespread badger culling on
tuberculosis in cattle.
Nature 439 (7078) 843-846.
Ewer K, Cockle P, Gordon S,
Mansoor H, Govaerts M, Walravens K,
Marche S, Hewinson G, Vordermeier M
2006
Antigen mining with iterative genome
screens identifies novel diagnostics for
the Mycobacterium tuberculosis complex.
Clinical and Vaccine Immunology 13 (1)
90-97.
Fend R, Geddes R, Lesellier S,
Vordermeier HM, Corner LAL,
Gormley E, Costello E, Hewinson RG,
Marlin DJ, Woodman AC, Chambers MA
2005
Use of an electronic nose to diagnose
Mycobacterium bovis infection in badgers
and cattle.
Journal of Clinical Microbiology 43 (4)
1745-1751.
Ferrand RA, Bothamley GH, Whelan A,
Dockrell HM 2005
Interferon-gamma responses to ESAT-6 in
tuberculosis patients early into and after
anti-tuberculosis treatment.
International Journal of Tuberculosis and
Lung Disease 9 (9) 1034-1039.
Gilbert M, Mitchell A, Bourn D,
Mawdsley J, Clifton-Hadley R, Wint W
2005
Cattle movements and bovine
tuberculosis in Great Britain.
Nature 435 (7041) 491-496.
Gordon SV, Cadmus S, Oluwasola A
2005
Molecular methods needed for the
accurate assessment of Mycobacterium
bovis infection.
International Journal of Tuberculosis and
Lung Disease 9 (6) 704.
Gous TA, Janse van Rensburg WJ,
Gray M, Perrett LL, Brew SD,
Young EJ, Whatmore AM, Gers S,
Picard J 2005
Brucella canis in South Africa.
Veterinary Record 157 (21) 668.
Hewinson RG, Vordermeier HM,
Smith NH, Gordon SV 2006
Recent advances in our knowledge of
Mycobacterium bovis: a feeling for the
organism.
Veterinary Microbiology 112 (2-4) 127-
139.
Hogarth PJ, Logan KE, Ferraz JC,
Hewinson RG, Chambers MA 2006
Protective efficacy induced by
Mycobacterium bovis bacille Calmette-
Guerin can be augmented in an antigen
independent manner by use of noncoding
plasmid DNA.
Vaccine 24 (1) 95-101.
Hogarth PJ, Logan KE,
Vordermeier HM, Singh M,
Hewinson RG, Chambers MA 2005
Protective immunity against
Mycobacterium bovis induced by
vaccination with Rv3109c - a member of
the esat-6 gene family.
Vaccine 23 (20) 2557-2564.
Hope JC, Thom ML, Villarreal-Ramos B,
Vordermeier HM, Hewinson RG,
Howard CJ 2005
Exposure to Mycobacterium avium
induces low-level protection from
Mycobacterium bovis infection but
compromises diagnosis of disease in
cattle.
Clinical and Experimental Immunology
141 (3) 432-439.
Hotter GS, Wards BJ, Mouat P, Besra GS,
Gomes J, Singh M, Bassett S,
Kawakami P, Wheeler PR, Lisle GW de,
Collins DM 2005
Transposon mutagenesis of Mb0100 at
the ppe1-nrp locus in Mycobacterium
bovis disrupts phthiocerol dimycocerosate
(PDIM) and glycosylphenol-PDIM
biosynthesis, producing an avirulent strain
with vaccine properties at least equal to
those of M.bovis BCG.
Journal of Bacteriology 187 (7) 2267-
2277.
Jungersen G, Sorensen V, Giese SB,
Stack JA, Riber U 2006
Differentiation between serological
responses to Brucella suis and Yersinia
enterocolitica serotype O:9 after natural
or experimental infection in pigs.
Epidemiology and Infection 134 (2) 347-
357.
Khan LA, Loria GR, Ramirez AS,
Nicholas RAJ, Miles RJ, Fielder MD
2005
Biochemical characterisation of some non
fermenting, non arginine hydrolysing
mycoplasmas of ruminants.
Veterinary Microbiology 109 (1-2) 129-
134.
Logan KE, Chambers MA,
Hewinson RG, Hogarth PJ 2005
Frequency of IFN-gamma producing cells
correlates with adjuvant enhancement of
bacille Calmette-Guerin induced
protection against Mycobacterium bovis.
Vaccine 23 (48-49) 5526-5532.
Loria GR, Tamburello A, Liga F, Lawes J,
Nicholas RJ 2005
Isolation of mycoplasmas from pigeons
suffering eye lesions and respiratory
disease.
Veterinary Record 157 (21) 664-665.
Mathews F, Macdonald DW, Taylor GM,
Gelling M, Norman RA, Honess PE,
Foster R, Gower CM, Varley S, Harris A,
Palmer S, Hewinson G, Webster JP
2006
Bovine tuberculosis (Mycobacterium
bovis) in British farmland wildlife: the
importance to agriculture.
Proceedings of the Royal Society B 273
(1584) 357-365.
McAuliffe L, Ellis RJ, Lawes JR,
Ayling RD, Nicholas RAJ 2005
16S rDNA PCR and denaturing gradient
gel electrophoresis; a single generic test
for detecting and differentiating
mycoplasma species.
Journal of Medical Microbiology 54 (8)
731-739.
McAuliffe L, Ellis RJ, Miles K,
Ayling RD, Nicholas RAJ 2006
Biofilm formation by mycoplasma species
and its role in environmental persistence
and survival.
Microbiology 152 (4) 913-922.
McCorry T, Whelan AO, Welsh MD,
McNair J, Walton E, Bryson DG,
Hewinson RG, Vordermeier HM,
Pollock JM 2005
Shedding of Mycobacterium bovis in the
nasal mucus of cattle infected
experimentally with tuberculosis by the
intranasal and intratracheal routes.
Veterinary Record 157 (20) 613-618.
Miles K, Churchward CP, McAuliffe L,
Ayling RD, Nicholas RAJ 2006
Identification and differentiation of
European and African/Australian strains of
Mycoplasma mycoides subspecies
mycoides small-colony type using
polymerase chain reaction analysis.
Journal of Veterinary Diagnostic
Investigation 18 (2) 168-171.
Miles K, McAuliffe L, Persson A,
Ayling RD, Nicholas RAJ 2005
Insertion sequence profiling of UK
Mycoplasma bovis field isolates.
Veterinary Microbiology 107 (3-4) 301-
306.
Mitchell A, Bourn D, Mawdsley J,
Wint W, Clifton-Hadley R, Gilbert M
2005
Characteristics of cattle movements in
Britain - an analysis of records from the
cattle tracing system.
Animal Science 80 (3) 265-273.
Monies B, Jahans K, Rua R de la 2006
Bovine tuberculosis in cats.
Veterinary Record 158 (7) 245-246.
Mostowy S, Inwald J, Gordon S,
Martin C, Warren R, Kremer K, Cousins D,
Behr MA 2005
Revisiting the evolution of Mycobacterium
bovis.
Journal of Bacteriology 187 (18) 6386-
6395.
Nicholas RAJ, Al-Momani W,
McAuliffe L, Ayling RD,
Abo-Shehada MN 2005
A re-assessment of the mycoplasma flora
of sheep.
In: Proceedings 6th International Sheep
Veterinary Congress, 17-21 June 2005,
258-259.
Nicholas RAJ, Ayling RD, Woodger N,
Houlihan MG 2005
Mycoplasmas in adult cattle: bugs worth
bothering with?
Cattle Practice 13 (2) 167-170.
Nielsen K, Smith P, Yu W, Nicoletti P,
Jungersen G, Stack J, Godfroid J 2006
Serological discrimination by indirect
enzyme immunoassay between the
antibody response to brucella sp. and
Yersinia enterocolitica O:9 in cattle and
pigs.
Veterinary Immunology and
Immunopathology 109 (1-2) 69-78.
Patel H, Mackintosh D, Ayling R,
Nicholas RAJ, Fielder MD 2005
The characterisation of a high yielding
growth medium for Mycoplasma
ovipneumoniae, a cause of atypical
pneumonia in sheep and goats.
In: Proceedings 6th International Sheep
Veterinary Congress, 17-21 June 2005,
263-264.
Perrett LL, Stack JA, Young EJ 2005
Characterisation of Brucella melitensis.
In: Proceedings 6th International Sheep
Veterinary Congress, 17-21 June 2005,
367.
Pitcher DG, Nicholas RAJ 2005
Mycoplasma host specificity: fact or
fiction?
Veterinary Journal 170 (3) 300-306.
Regan EJ, Harrison GAJ, Butler S,
McLauchlin J, Thomas M, Mitchell S
2005
Primary cutaneous listeriosis in a
veterinarian.
Veterinary Record 157 (7) 207.
Renshaw PS, Lightbody KL, Veverka V,
Muskett FW, Kelly G, Frenkiel TA,
Gordon SV, Hewinson RG, Burke B,
Norman J, Williamson RA, Carr MD 2005
Structure and function of the complex
formed by the tuberculosis virulence
factors CFP-10 and ESAT-6.
EMBO Journal (2005) 1-8.
Saleem IY, Vordermeier M, Barralet JE,
Coombes AGA 2005
Improving peptide-based assays to
differentiate between vaccination and
Mycobacterium bovis infection in cattle
using nanoparticle carriers for adsorbed
antigens.
Journal of Controlled Release 102 (3)
551-561.
Scott JC, Wright DJM, Cutler SJ 2005
Typing African relapsing fever
spirochetes.
Emerging Infectious Diseases 11 (11)
1722-1729.
Skinner MA, Wedlock DN, Lisle GW de,
Cooke MM, Tascon RE, Ferraz JC,
Lowrie DB, Vordermeier HM,
Hewinson RG, Buddle BM 2005
The order of prime-boost vaccination of
neonatal calves with Mycobacterium
bovis BCG and a DNA vaccine encoding
mycobacterial proteins Hsp65, Hsp70,
and Apa is not critical for enhancing
protection against bovine tuberculosis.
Infection and Immunity 73 (7) 4441-
4444.
Smith NH, Kremer K, Inwald J, Dale J,
Driscoll JR, Gordon SV, Soolingen D van,
Hewinson RG, Smith JM 2006
Ecotypes of the Mycobacterium
tuberculosis complex.
Journal of Theoretical Biology 239 (2)
220-225.
Stack JA, Perrett LL, Commander NJ
2005
Brucellosis and ovine epididymitis.
In: Proceedings 6th International Sheep
Veterinary Congress, 17-21 June 2005,
297-298.
Vordermeier HM, Huygen K, Singh M,
Hewinson RG, Xing Z 2006
Immune responses induced in cattle by
vaccination with a recombinant
adenovirus expressing mycobacterial
antigen 85A and Mycobacterium bovis
BCG.
Infection and Immunity 74 (2) 1416-
1418.
Vordermeier HM, Chambers MA,
Buddle BM, Pollock JM, Hewinson RG
2006
Progress in the development of vaccines
and diagnostic reagents to control
tuberculosis in cattle.
Veterinary Journal 171 (2) 229-244.
Vordermeier HM, Pontarollo R,
Karvonen B, Cockle P, Hecker R,
Singh M, Babiuk LA, Hewinson RG,
Drunen Littel-van Den Hurk S van 2005
Synthetic peptide vaccination in cattle:
induction of strong cellular immune
responses against peptides derived from
the Mycobacterium bovis antigen
Rv3019c.
Vaccine 23 (35) 4375-4384.
Vordermeier M, Goodchild A,
Clifton-Hadley R, Rua R de la 2005
The interferon-gamma field trial:
background, principles and progress.
Cattle Practice 13 (4) 323-325.
In: Proceedings 6th International Sheep
Veterinary Congress, 17-21 June 2005,
297-298.
Vordermeier M, Hogarth P 2005
Vaccine development in the 21st century:
a time of living dangerously.
Veterinary Journal 170 (3) 271-272.
Wangoo A, Johnson L, Gough J,
Ackbar R, Inglut S, Hicks D,
Spencer Y, Hewinson G,
Vordermeier M 2005
Advanced granulomatous lesions in
Mycobacterium bovis-infected cattle are
associated with increased expression of
type I procollagen, gammadelta (WC1+) T
cells and CD 68+ cells.
Journal of Comparative Pathology 133 (4)
223-234.
Wedlock DN, Denis M, Skinner MA,
Koach J, Lisle GW de, Vordermeier HM,
Hewinson RG, Drunen Littel-van den
Hurk S van, Babiuk LA, Hecker R,
Buddle BM 2005
Vaccination of cattle with a CpG
oligodeoxynucleotide-formulated
mycobacterial protein vaccine and
Mycobacterium bovis BCG induces levels
of protection against bovine tuberculosis
superior to those induced by vaccination
with BCG alone.
Infection and Immunity 73 (6) 3540-
3546.
Wedlock DN, Skinner MA, Lisle GW de,
Vordermeier HM, Hewinson RG,
Hecker R, Drunen Littel-van den Hurk S
van, Babiuk LA, Buddle BM 2005
Vaccination of cattle with Mycobacterium
bovis culture filtrate proteins and CpG
oligodeoxynucleotides induces protection
against bovine tuberculosis.
Veterinary Immunology and
Immunopathology 106 (1-2) 53-63.
Wheeler PR, Coldham NG, Keating L,
Gordon SV, Wooff EE, Parish T,
Hewinson RG 2005
Functional demonstration of reverse
transsulfuration in the Mycobacterium
tuberculosis complex reveals that
methionine is the preferred sulfur source
for pathogenic mycobacteria.
Journal of Biological Chemistry 280 (9)
8069-8078.
Wilkinson KA, Simsova M, Scholvinck E,
Sebo P, Leclerc C, Vordermeier HM,
Dickinson SJ, Brown JR, Davidson RN,
Pasvol G, Levin M, Wilkinson RJ 2005
Efficient ex vivo stimulation of
Mycobacterium tuberculosis - specific T
cells by genetically detoxified Bordetella
pertussis adenylate cyclase antigen
toxoids.
Infection and Immunity 73 (5) 2991-
2998.
Woodroffe R, Donnelly CA, Johnston WT,
Bourne FJ, Cheeseman CL,
Clifton-Hadley RS, Cox DR, Gettinby G,
Hewinson RG, Le Fevre AM,
McInerney JP, Morrison WI 2005
Spatial association of Mycobacterium
bovis infection in cattle and badgers
Meles meles.
Journal of Applied Ecology 42 (5) 852-
862.
Xing Z, Santosuosso M, McCormick S,
Yang TC, Millar J, Hitt M, Wan YH,
Bramson J, Vordermeier HM 2005
Recent advances in the development of
adenovirus- and poxvirus-vectored
tuberculosis vaccines.
Current Gene Therapy 5 (5) 485-492.
